Abstract
BackgroundHantavirus is a tripartite negative-sense RNA virus. It can infect humans through contaminated rodent excreta and causes two types of fatal human diseases: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). China exhibits the highest HFRS occurrence rate in the world, and the Heilongjiang area is one of the most severely infected regions.ResultsTo obtain additional insights into the genetic characteristics of hantaviruses in the port cities of the Heilongjiang area in China, a molecular epidemiological investigation of hantaviruses isolated from rodents was performed in 2014. A total of 649 rodents (11 murine species and 1 shrew species) were caught in 12 port cities in Heilongjiang. Among these rodents, the most common species was A. agrarius, and the second-most common was R. norvegicus. A viral gene PCR assay revealed the presence of two specific genotypes of hantavirus, referred to as Hantaan virus (HTNV) and Seoul virus (SEOV), and the positive SEOV infection rate was higher than that for HTNV. A genetic analysis based on partial M segment sequences indicated that all of the isolates belonging to SEOV could be assigned to two genetic lineages, whereas the isolate belonging to HTNV could be assigned to only one genetic lineage.ConclusionsThese results suggested that HTNV and SEOV are circulating in A. agrarius and R. norvegicus in the port cities in the area of Heilongjiang, but SEOV may be the dominant common hantavirus.
Highlights
Hantavirus is a tripartite negative-sense RNA virus
The Heilongjiang area harbors a diversity of species, with A. agrarius and R. norvegicus representing the dominant species
The results showed that the infection rate of A. agrarius was 4.9 %, and the infection rate of R. norvegicus was 8.3 % (Table 1)
Summary
Hantavirus is a tripartite negative-sense RNA virus. It can infect humans through contaminated rodent excreta and causes two types of fatal human diseases: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). Hantaviruses, which belong to the Hantavirus genus in the Bunyaviridae family, are tripartite negative-sense RNA viruses. Unlike other viruses of the Bunyaviridae family, hantaviruses are not transmitted by arthropods; rather, they infect people though the Etiological studies have shown that HFRS that has spread around the world, resulting in the production of variant hantaviruses. In Asia and Europe, five types of hantaviruses can cause HFRS: Hantaan virus (HTNV), Seoul virus (SEOV), Dobrava virus (DOBV), Saaremaa virus (SAAV), and Puumala virus (PUUV) [14]. Most HFRS cases occur in Europe and East Asia (Korea, Cao et al BMC Veterinary Research (2016) 12:69
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