Abstract
Timely identification of pandemic influenza threats depends on monitoring for highly pathogenic avian influenza viruses. We isolated highly pathogenic avian influenza A(H5N6) virus clade 2.3.4.4, genotype G1.1, in samples from a bird in southwest Russia. The virus has high homology to human H5N6 influenza strains isolated from southeast China.
Highlights
Identification of pandemic influenza threats depends on monitoring for highly pathogenic avian influenza viruses
Using H5 clade nomenclature designated by the World Health Organization/World Organisation for Animal Health/ Food and Agriculture Organization H5 Evolution Working Group (4), our phylogenetic analysis showed that hemagglutinin (HA) gene of A/common gull/Saratov/1676/2018 clusters with Highly pathogenic avian influenza (HPAI) viruses in clade 2.3.4.4 H5N6-H5/Major lineage
Our analyses show this strain belongs to a new HA subgroup that includes human H5N6 viruses isolated in Guangxi and Guangdong Provinces, China, in 2018 (Appendix Figure 1, Table 1, https://wwwnc.cdc.gov/EID/ article/25/12/19-0504-App1.pdf)
Summary
Identification of pandemic influenza threats depends on monitoring for highly pathogenic avian influenza viruses. Pathogenic avian influenza (HPAI) H5 virus continues to evolve and pose a threat to animals and humans. We used whole-genome sequencing to extract the virus DNA and conducted a phylogenetic analysis against strains available in the GISAID EpiFlu database (http:// www.gisaid.org).
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