Abstract
Aim – Our goal is to pinpoint genetic markers that could increase the risk of developing PTSD. Identifying these markers can guide future research aimed at creating preventive measures and treatments for PTSD.
 Material and methods. We searched the PubMed database and found 623 articles. After screening, 20 articles met our criteria: they were published between 2018 and 2023, involved original research with molecular-genetic and statistical data, confirmed PTSD diagnoses, and had a sample size of at least 60 patients.
 Results. Our analysis of the 20 studies revealed significant links between PTSD and several genetic factors: FKBP5 SNV rs9470080, regardless of the C or T allele; two FKBP5 haplotypes (A-G-C-C and A-G-C-T); gene-gene DRDхANNK1-COMT (rs1800497 × rs6269) and OXTR–DRD2 (rs2268498 × rs1801028); C-allele of CRHR1 (rs1724402). However, other findings, such as the association of other FKBP5 haplotypes and the FKBP5-CRHR1 genotype, were less clear and require further study.
 Conclusions. While our analysis suggests that genetics play a role in PTSD, our understanding of how genetic factors contribute to the disorder is still limited. Future research should delve deeper into these genetic mechanisms, including the role of epigenetics, to gain a better understanding of PTSD and develop more effective treatments.
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