Abstract
Systemic sclerosis (SSc) is a complex rheumatic disease characterized by fibrosis of the skin and internal organs, vasculopathy, and autoimmunity (Denton and Khanna, 2017). Although the exact etiology of SSc remains unclear, genetic factors contribute significantly to SSc pathogenesis. A total of seven GWAS studies have identified 34 non–major histocompatibility complex loci associated with SSc at the genome-wide significance level (Ota and Kuwana, 2021). However, the majority of these genes were discovered in Caucasians, with other ethnicities underrepresented.
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