Genetic association of IL2RA, IL17RA, IL23R, and IL31RA single nucleotide polymorphisms with alopecia areata

Abstract

The signalling of cytokine receptors plays a crucial role in regulating tolerance and immunity. Impaired immunological processes result in autoimmune inflammation that target the hair follicles, causing many hair disorders, mainly alopecia areata (AA). Therefore, polymorphisms in cytokine receptor genes are suggested to have a significant impact on the pathogenesis of AA, a disease with a multifactorial basis and uncertain etiology. In the present study, 152 AA patients of the Jordanian population were investigated for their genetic susceptibility to develop AA compared to 150 control subjects. Genomic DNA extraction and genotyping had conducted forIL17RA(rs879575, rs2229151, and rs4819554),IL2RA(rs3118470),IL23R(rs10889677), andIL31RA(rs161704) using the Sequenom MassARRAY® system. The allele frequency ofIL17RArs879575 is significantly higher in patients, while no statistical differences were found forIL2RA, IL23R,andIL31RASNPs. Also, the recessive model ofIL31RArs161704 showing that AA genotype is significantly associated with AA development. To date, there is no published data regarding the association between AA and the selected genetic variants in our population. However, this study's findings assert that SNPs ofIL17RAandIL31RAare linked to AA susceptibility in Jordanian patients.