Abstract
Background The role of the NFKB1 gene rs28362491 polymorphism and NFKBIA gene rs2233406 polymorphism in the development of head and neck cancer (HNC) remains controversial. This meta-analysis was performed to assess the relationship between the gene polymorphisms and HNC quantitatively. Methods PubMed, Embase, Web of Science, WanFang Data, and China National Knowledge databases were used to search for eligible articles. The relationship was evaluated by STATA 11.0. Results Eight eligible articles were included in our study. Nine case-control studies from the eight included articles were correlated with rs28362491 polymorphism. Four articles were related to rs2233406 polymorphism. Overall, a significant correlation was observed between the rs28362491 polymorphism and a decreased risk of HNCs (OR = 0.76, 95%CI = 0.60‐0.97 for DD vs. II; OR = 0.80, 95%CI = 0.68‐0.95 for DD vs. DI+II). In subgroup analyses, the rs28362491 polymorphism was associated with the risk of nasopharyngeal carcinoma (NC), but not with oral cancer (OC). In addition, no statistical correlation was found between the polymorphism of rs2233406 and HNCs. Conclusion rs28362491 polymorphism was significantly associated with the risk of HNCs, especially with NC. Additionally, our results showed that no association was discovered between rs2233406 polymorphism and HNCs.
Highlights
Head and neck cancer (HNC) is the sixth most common cancer [1], which arises in the oral cavity, pharynx, nasal cavity, and larynx
The primary etiology of head and neck cancer (HNC) is related to human papillomavirus (HPV), smoking, alcohol, and Epstein-Barr virus (EBV) infection [6,7,8,9,10], only a small number of subjects exposed to these risk factors will suffer from a HNC, which suggests that individual genetic susceptibility might be strongly correlated with the development of HNCs [3, 11, 12]
The results showed that -94 ins/del ATTG polymorphism was significantly correlated with a decreased risk of HNCs under homozygote and recessive genetic models (OR = 0 76, 95% confidence intervals (CIs) = 0 60‐0 97 for DD vs. II, Figure 2; odds ratio (OR) = 0 80, 95%CI = 0 68‐0 95 for DD vs. DI+II)
Summary
Head and neck cancer (HNC) is the sixth most common cancer [1], which arises in the oral cavity, pharynx, nasal cavity, and larynx. The role of the NFKB1 gene rs28362491 polymorphism and NFKBIA gene rs2233406 polymorphism in the development of head and neck cancer (HNC) remains controversial. This meta-analysis was performed to assess the relationship between the gene polymorphisms and HNC quantitatively. Nine case-control studies from the eight included articles were correlated with rs28362491 polymorphism. The rs28362491 polymorphism was associated with the risk of nasopharyngeal carcinoma (NC), but not with oral cancer (OC). Rs28362491 polymorphism was significantly associated with the risk of HNCs, especially with NC. Our results showed that no association was discovered between rs2233406 polymorphism and HNCs
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