Abstract
Purpose. To study the distribution and to investigate the associative links of the IL-1β-511CT gene polymorphism and frequency of tandem repeats of the gene IL-1RA in children of Chernivtsy region with complicated gastrointestinal bleeding ulcer. Material and methods. The study involved 94 children with complicated gastrointestinal bleeding and uncomplicated peptic ulcer disease and 50 healthy children aged 7-18 years who lived in the Chernivtsy region and the city of Chernivtsy. Genetic polymorphisms of genes IL-1β-511CT and IL-1RA in children was defined by polymerase chain reaction. Results. The risk of bleeding in children with uncomplicated illness doubled in the presence of the alleles of IL-1β-511*T, and 5,0 and 5,79 times - R2 alleles of IL-1RА and genotype R2R2-IL-1RA. Genotype of the IL-1β-511СС and R2R2-IL-1PА carriage increases the risk of bleeding ulcer in healthy children at 3,50 and 2,88 times. Conclusion. The study of genetic polymorphism of genes made possible to identify the factors of increased risk of gastrointestinal bleeding cased by ulcer and protective factors.
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