Abstract
We have investigated associations between anti-DNA antibody production and MHC class II alleles in children of Georgian nationality with Systemic Lupus Erythematosus (SLE). Analysis showed that HLA-DR3 was related to the presence of anti-native, double-stranded (ds) DNA. In contrast, antibodies to single stranded (ss) DNA were associated with HLA-DR5. Patients with seronegative lupus exhibited excess DR2 phenotype. These results suggest that subsets of SLE patients can be defined by MHC and serological markers in this population and raises the question of the role of HLA D region genes in disease expression.
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