Abstract
Genetic and Molecular Aspects of Thyrotoxic Cardiomyopathy
Highlights
In this review we focused on the cardiomyopathy, which develops secondary to thyrotoxicosis
Recent studies have shown the associations of different thyrotoxic cardiomyopathy (TCMP) components with single nucleotide polymorphisms (SNPs) in genes encoding proteins involved in thyroid hormones effects on tissues and arrhythmogenesis
The findings indicate that KCNE1 gene is α-thyroid receptors targets and is regulated by thyroid status: a marked decrease in min K mRNA occurs in hyperthyroid mice’ hearts and hearts of T3β-receptor knockout mice [6]
Summary
In this review we focused on the cardiomyopathy, which develops secondary to thyrotoxicosis. The investigation of molecular and genetic basis of thyrotoxic cardiomyopathy (TCMP) can improve treatment strategies and provide new potential drug targets for its therapy. Increasing understanding of the pathophysiology of TCMP will improve risk prediction of severe cardiovascular complication in patients with thyrotoxicosis.
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