Abstract
We review progress made concerning the participation of candidate genes in the determination of attention deficit disorder with hyperactivity (ADHD) as well as recent evidence on its genetic determination based on molecular methodology. In addition to linkage analyses, we discuss recent results obtained through genome-wide association studies (GWAS). We also discuss the genetic comorbidity estimated between ADHD and major psychiatric disorders such as schizophrenia (E), major depressive disorder (MDD), bipolar disorder (BD), and autism spectrum disorders (ASD). Furthermore, we examine both the geographical distribution of DRD4 and cross-ethnic variation of ADHD risk in Chilean children. Finally, visualizing ADHD from an evolutionary perspective, we suggest that behavioral traits such as hyperactivity, inattention, impulsivity, and sexual arousal, which play a role in ADHD could have had a high adaptive value during the early stages of the evolution of Homo sapiens but turned progressively less adaptive and more recently definitively disadvantageous.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
