Abstract
The molecular genetic mechanisms of colorectal cancer are among the best understood of any common cancer. Recent research has identified mutated tumor suppressor genes and oncogenes as normal tissue progresses from benign to malignant, and the novel mismatch repair genes involved in a specific form of hereditary colorectal cancer as well as a significant percentage of sporadic cases. This information has led to a better understanding of the inheritance of large bowel cancer, as well as a model of tumorigenesis which proposes a multistep process as colonic epithelial cells progress from their normal state through successive stages of adenoma to malignancy. Exogenous factors such as fiber and fat are important modifiers of inherited risk. Dietary factors may influence the carcinogenic process by modifying intestinal transit time, altering the flow and recycling of bile, or changing the intestinal bacterial flora composition. A number of studies have also suggested the modulation of risk in both hereditary syndromes and sporadic cases with certain micronutrients or medications like nonsteroidal anti-inflammatories.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
