Abstract
BackgroundHigher insulin-like growth factor (IGF)-1 and lower IGF binding protein (BP)-3 levels have been associated with higher commoncancer risk, including breast cancer. Dietary factors, genetic polymorphisms, and the combination of both may influence circulating IGF-1 and IGFBP-3 serum concentrations.MethodsFrom September 2011 to July 2012, we collected demographic, reproductive and dietary data on 143 women (≥40 years). We genotyped IGF-1 rs1520220 and IGFBP-3 rs2854744 and measured circulating IGF-1 and IGFBP-3 levels in serum. Covariance analyses were used to estimate the associations of serum levels of IGF-1 and IGFBP-3, and the molar ratio of IGF-1to IGFBP-3 with IGF-1 rs1520220 and IGFBP-3 rs2854744 genotypes. We subsequently assessed the combined influence of genetics and diet (daily intake of protein, fat and soy isoflavones) on IGF-1 and IGFBP-3 levels.ResultsAmong women aged less than 50 years, circulating IGF-1 serum levels were significantly lower for those with CC genotype for IGF-1 rs1520220 than levels for those with the GC or GG genotypes (in recessive model: P = 0.007).In gene-diet analyses among these women, we found carrying CC genotype for IGF-1 rs1520220 and high soy isoflavone intake tend to be associated with lower circulating IGF-1 levels synthetically (P = 0.002). Women with GG or GC genotypes for IGF-1 rs1520220 and with low intake of soy isoflavones had the highest levels of circulating IGF-1 (geometric mean [95% CI]: 195 [37, 1021] µg/L). Comparatively, women with both the CC genotype and high soy intake had the lowest levels of circulating IGF-1 (geometric mean [95% CI]: 120 [38,378] µg/L).ConclusionsIGF-1 serum levels are significantly lower among women with the CC genotype for IGF-1-rs1520220. High soy isoflavone intake may interact with carrying CC genotype for IGF-1-rs1520220 to lower women's serum IGF-1 levels more.
Highlights
The insulin-like growth factor (IGF) -system mainly consists of IGF-1, IGF-2, IGF receptors (IGF-1R and IGF-2R), and six binding proteins (IGFBP-1-6)
Two twin studies estimated that approximately 40%–60% of inter-individual differences in circulating levels of IGF-1 and IGFBP-3 are attributed to heritable factors, such as single nucleotide polymorphisms (SNPs) [23,24]
We examined the main effects of dietary intake and genetic polymorphisms on circulating IGF-1 and IGFBP-3 concentrations among women aged 40 years or older, a population with high breast cancer incidence in China [40]
Summary
The insulin-like growth factor (IGF) -system mainly consists of IGF-1, IGF-2, IGF receptors (IGF-1R and IGF-2R), and six binding proteins (IGFBP-1-6). Two twin studies estimated that approximately 40%–60% of inter-individual differences in circulating levels of IGF-1 and IGFBP-3 are attributed to heritable factors, such as single nucleotide polymorphisms (SNPs) [23,24]. The associations of both SNPs with circulating IGF-1 and IGFBP-3 levels is not clear in the Chinese population as few studies have focused on this population. Exogenous factors, including both hormonal and nutritional, may have an important influence on circulating IGF-1 and IGFBP-3 levels [30]. Higher insulin-like growth factor (IGF)-1 and lower IGF binding protein (BP)-3 levels have been associated with higher commoncancer risk, including breast cancer. Genetic polymorphisms, and the combination of both may influence circulating IGF-1 and IGFBP-3 serum concentrations
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