Abstract

T helper cells for the promotion of Sendai virus-specific antibody production were generated in vitro. They could be stimulated by infectious, UV light-inactivated or fusion-negative Sendai virus, which had to be presented by adherent cells. Induction of T helper cells was virus-specific and required H-2 IA region compatibility between T cells and antigen-presenting cells. Delivery of help to B lymphocytes was neither virus-specific nor H-2-restricted.

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