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Abstract
SUMMARYH‐1d and H‐11 serologically identical combinations of inbred rat strains were studied, in which there was a strong mixed lymphocyte reaction (MLR). The H‐1d identical combination was formed with the Maudsley reactive (MR) and BD IX strains, in which there was bidirectional stimulation. The LAD differences in the combination BD IX and MR were shown in experiments using back‐crosses derived from two different sources, BD IX x LEW and MR x LEW.The H‐11 identical combination was the F344 (Fisher) and LEW (Lewis) strains; here the MLR was unidirectional—LEW stimulating F344. Two other H‐11 serologically identical strains, AS and HCS, also stimulated F344 lymphocytes. Genetic segregation analyses using back‐crosses showed linkage with H‐1 in both instances. The LADs of AS, HCS and LEW appeared to be the same.These experiments show that the rat LADs so far detectable using these strains are all encoded by genes linked to the major histocompatibility system of the rat, despite serological identity. In addition to disassociation of the major histocompatibility system antigens detected by serological means and those defined by MLC testing, there was also disassociation of transplantation antigens as shown in the BD IX x MR model.
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