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Abstract
Allelic sequencing combined with comparative analyses of population-specific haplotypes have provided persuasive evidence that the Type 1 diabetes susceptibility determinants associated and linked to the MHC class II region are partly due to DQ allelic polymorphism. A central role for an immune response molecule in this disease is consistent with many of the features of Type 1 diabetes. Identification of autoantigens and cloning of pathogenic T cells will help elucidate the roles of class II alleles in disease. This and mapping of other genes both inside and outside the MHC will eventually lead to a way of preventing or at least decreasing beta cell destruction.
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