Abstract
We assessed contribution of genetic factors to the infiltrative pulmonary tuberculosis development using the association analysis. Analysis of polymorphisms in TNFA (-308G>A) ( p < 0.01), CYP1A1 (Ile462Val) ( p < 0.05), and GSTM1 (deletion) ( p < 0.00001) genes revealed statistically significant differences between patients with infiltrative pulmonary tuberculosis and control subjects. This information could be used to form the highrisk group for the pulmonary tuberculosis development and to predict its occurrence.
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