Genetic Analysis of LRRK2 R1628P in Parkinson's Disease in Asian Populations.

Yuan Zhang,Qiying Sun,Jifeng Guo,Xinxiang Yan,Qian Xu,Xun Zhou,Minhan Yi,Beisha Tang

doi:10.1155/2017/8093124

Abstract

Although the etiology of Parkinson's disease (PD) remains unclear, there is increasing evidence of genetic factors contributing to the onset of PD. Various mutations and risk variants of the gene LRRK2 have been reported, but the association between LRRK2 R1628P and PD is still inconsistent. Thus, we conducted a meta-analysis to determine the potential relationship between R1628P and PD. Our study sample was an aggregate of 17 publications, which in total consisted of 9,275 PD patients and 8,114 controls. All of these articles are of high quality according to NOS, and there was no obvious reporting bias or heterogeneity. In a general Asian population, the pooled OR of the risk genotype contrasts was 1.83 (95% CI: 1.57, 2.13). When stratified by ethnicity, the pooled ORs were 1.84 (95% CI: 1.56, 2.18) in a Chinese population and 1.79 (95% CI: 1.27, 2.52) in a non-Chinese population. Our study suggests that LRRK2 R1628P appears to be a risk factor for PD in Asian populations, both Chinese and non-Chinese.

Highlights

Parkinson’s disease (PD) is currently the second most common progressive neurodegenerative disorder in the world
20 publications were excluded for irrelevance to both PD and R1628P, which was determined after screening the titles and abstracts. 14 papers were not included for lack of sequencing results of R1628P both in PD patients and in controls, or the data was not enough to calculate the odds ratio (OR)
All included publications were of high quality according to Newcastle–Ottawa Scale (NOS) and the results were stable during sensitive analysis

Summary

Introduction

Parkinson’s disease (PD) is currently the second most common progressive neurodegenerative disorder in the world. Current science has not been able to discern the exact causes of PD, there is an increasing evidence that genetic factors contribute to the etiology of PD [1]. In Asian populations, the mostly common variants are G2385R and R1628P [8, 9]. Between these two variants, it is the association between R1628P and PD; that is inconclusive. A large multicenter study [14] and several other investigators [15,16,17] did not identify any associated risk of R1628P in either East Asian, Caucasian, or Arab-Berber cohorts

Methods

Results

Conclusion