Abstract
The new mutant LEC rat suffers from hereditary hepatitis with severe jaundice, anemia, subcutaneous bleeding, weight loss, and oliguria at around 4 months after birth [1, 2]. About one-half of the LEC rats die within 1 week after the onset of hepatitis, whereas the remaining LEC rats survive much longer with chronic hepatitis and subsequently develop liver cancer at a high frequency [3, 4].
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