Abstract
Isolation-induced fighting behavior, measured in a neutral arena for 5 min/day over a 5 day period differed significantly in C57BL/6By and BALB/cBy mice. Evaluation of this performance in reciprocal F 1 hybrids of these two inbred strains, and their recently developed recombinant inbred strains permitted the derivation of an hypothesis regarding possible genetic control of this behavior in mice. Additionally, examination was made regarding the possible influences of maternal social and uterine environments on fighting behavior. Tentative conclusion was reched that isolation-induced fighting behavior in mice is influenced by at least two homozygous loci, and a possible cytoplasmic factor of the ovum.
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