Abstract
Genetic analyses of inheritance of disease resistance in plants have demonstrated that resistance is often determined by single dominant or semi-dominant loci (-). Although many disease resistance genes have been characterized at a classical genetic level, the molecular cloning and biochemical characterization of most disease resistance genes remains to be accomplished (). In this regard, it is only within the last two years that Johal and Briggs have reported the successful transposon tagging and cloning of the Hml disease resistance gene of maize (). The Hml resistance locus of maize is a single dominant locus that confers resistance to Cochliobolus carbonum race 1 which is the causal agent of a severe leaf blight and ear mold disease of maize. This pathogen produces the host-specific toxin (HC-toxin) and Hml encoded resistance is also effective against the purified toxin (). Sequence information has revealed that Hml gene encodes a NADPH-dependent HC toxin reductase.
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