Genetic analyses of feline foamy virus isolates from domestic and wild feline species in geographically distinct areas

Abstract

To know the genetic diversities and phylogenetic relationship among feline foamy virus (FeFV) isolates from domestic cats ( Felis catus) and FeFV-related viruses from the Iriomote cats ( Felis iriomotensis) and leopard cats ( Felis bengalensis) in geographically distinct areas, we sequenced a partial gag– pol region of 17 strains and a partial env region of nine strains, and the U3 region of long terminal repeat of three strains of the viruses. FeFV-related viruses from the feral cats were quite similar to the FeFV from domestic cats in the sequenced regions. In the partial gag region, the identities of nucleotide sequences among the isolates were from 94 to 99%. In the partial env gene, the isolates were divided into two distinct genotypes (F17- and FUV-types) as reported by Winkler et al. (Virology 247 (1999) 144–151). More than 94% nucleotide identities were observed in the env region within a particular env genotype and about 75% nucleotide identities were noted between the two genotypes.