Abstract
Chorioamniotic separation (CAS) at the time of standard amniocentesis (AC) is a risk factor for postprocedural complications and should be avoided. The aim of this study was to quantify procedure-related risks after AC with a 29G-needle in cases of CAS, and evaluation of perinatal outcome in CAS after 15weeks' gestation (GW). Retrospective analysis of genetic AC with a pencil-point 29G needle after 15 completed GW in pregnancies, inwhich the fetal membranes were notyetfused. Included into the study were women aged16-44years with at least 15completed GWs referred for second trimester AC to identifyfetal chromosomal aberrations. 437 ACs were made in total with the 29G-needle. The median maternal age was 30 (16-44)years. 145 cases showed CAS where the distance between chorion and amnion was 0.10-10.02mm at AC. 38 pregnancies were terminated, 37 of which had a genetic disorder. The risk ofaneuploidy increases by a factor of 2 (95% CI 1.4-2.8) forevery 1mm of CAS enlargement. No procedure-related complications were found up to twoweeks after the AC. CAS seems to be massively underreported. Early diagnosis in case of CAS is something to strive for asCAS could be an indicator of genetic abnormalities- a "soft marker". With the atraumatic 29G needle, the risk ofcomplications after AC in CAS seems to be very low.
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