Abstract
The classic myelin basic proteins (MBPs) are a family of small membrane-associated proteins that are specifically expressed in myelin-forming cells. MBPs are extremely abundant in compact myelin, accounting for 30–40% of the total protein content in the CNS and 10–20% in the PNS. Initial molecular studies on the structure of the MBP gene identified the gene as ∼32 kb in length and comprised of seven exons [1,2]. The MBP gene was found to map to chromosome 18 in the mouse and human and, by alternative RNA splicing, code for all of the known MBP isoforms [1,3–6].
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