Genetic algorithm to optimization mobility-based dengue mathematical model

Abstract

<span lang="EN-US">Implementation of vaccines, mosquito repellents and several Wolbachia schemes have been proposed recently as strategies against dengue. Research showed that the use of vaccine and repellent is highly effective when implemented to individuals who are in area with high transmission rates, while the use of Wolbachia bacteria is strongly effective when implemented in area with low transmission rates. This research is to show a three-strategy combination to cope with the dengue using mathematical model. In dengue mathematical model construction, several parameters are not yet known, therefore a genetic algorithm method was used to estimate dengue model parameters. Numerical simulation results showed that the combination of three strategies were able to reduce the number of infected humans. The dynamic of the human population with the combination of three strategies on average was able to reduce the infected human population by 45.2% in immobility aspect. Furthermore, the mobility aspect in dengue model was presented by reviewing two areas; Yogyakarta and Semarang in Indonesia. The numerical solutions showed that the trend graph was almost similar between the two areas. With the maximum effort given, the combination control values decreased slowly until the 100<sup>th</sup> day.</span>