Abstract
Metal pollution poses significant threats to the ecosystem and human health, demanding effective remediation strategies. Bioremediation, which leverages the unique metal-resistant genes found in bacteria, offers a cost-effective and efficient solution to heavy metal contamination. Genes such as Cad, Chr, Cop, and others provide pathways to improve the detoxification of the ecosystem. Through multiple techniques, genetic engineering makes bacterial genomes more capable of improving metal detoxification; nonetheless, there are still unanswered questions regarding the nature of new metal-resistant genes. This article examines bacteria's complex processes to detoxify toxic metals, including biosorption, bioaccumulation, bio-precipitation, and bioleaching. It also explores essential genes, proteins, signaling mechanisms, and bacterial biomarkers involved in breaking toxic metals.
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