Abstract
Background. According to the World Health Organization, the atherosclerosis development depends on the quality of life and lifestyle (60 %), genetic (20 %), environmental factors (10 %) and quality of medical aid (5 %). The routes to defeat atherosclerosis generally and certain systemic enzyme disorders in particular pertain in research into the population genetic predispositions to this pathology.Materials and methods.A comparative study of genetic predispositions to malignant brachiocephalic atherosclerosis analysed the renin—angiotensin system gene association in 60 patients. Th e renin—angiotensin system allelic and polymorphic loci haplotype frequencies have been determined.Results and discussion. Patients with atherosclerotic brachiocephalic vascular lesions revealed a statistically significant frequency of the AGT gene’s allele C involved in coronary heart disease development.Conclusion. Th e study suggests a putative involvement of the angiotensinogen system genes in mediating the development of brachiocephalic atherosclerosis and coronary heart disease
Highlights
According to the World Health Organization, the atherosclerosis development depends on the quality of life and lifestyle (60 %), genetic (20 %), environmental factors (10 %) and quality of medical aid (5 %)
The study suggests a putative involvement of the angiotensinogen system genes in mediating the development of brachiocephalic atherosclerosis and coronary heart disease
Цель исследования — проведение сравнительного анализа генетической предрасположенности у пациентов злoкaчественнoго течения aтерoсклерoза бpaхиoцефaльных сосудов на основе исследования ассоциации генoв ренин-ангиoтензинoвой cиcтемы
Summary
According to the World Health Organization, the atherosclerosis development depends on the quality of life and lifestyle (60 %), genetic (20 %), environmental factors (10 %) and quality of medical aid (5 %). [11] обнаружена прямая корреляционная связь у пациентов с гетерозиготной семейной гиперхолестеринемией между инфарктом миокарда в анамнезе, толщиной интима-медиа комплекса сонных артерий, повышением концентрации PCSK-9 в крови и носительством аллеля G полиморфизма E670G гена PCSK-9, что позволяет использовать их в качестве прогностических маркеров риска развития сердечно-сосудистых осложнений. Все это говорит о том, что для более эффективного прогноза лечения и реабилитации данного контингента пациентов необходимо проведение генетического скрининга, по крайней мере, генов системы ангиотензиногена. Анализ полиморфного варианта Ins-Del в гене ACE у исследуемых пациентов Table 2.
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