Abstract
To examine cell generation in the frog retinal pigment epithelium (RPE), representative developmental stages from tail-bud to adulthood received a single injection of [ 3H]thymidine. Animals were killed either 24 h or several weeks later; eyes were sectioned and processed by standard autoradiographic procedures and viewed by epi-polarised illumination. The distribution of [ 3H]thymidine-labelled cells indicated that the RPE is formed throughout life, including in adulthood, by cell addition at the ciliary margin, matching the pattern for the neural retina. In addition, a very small number of peripapillary RPE cells underwent division but only in the adult.
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