Abstract
The outbreaks and quick spread of severe-acute-respiratory-syndrome-coronavirus 2 (SARS-CoV-2), causing the coronavirus disease 2019 (COVID-19), have badly affected the whole world due to continuous emergence-and-transmission of the latest-new viral-genomes forming new-variants revealing patterns of the SARS-CoV-2 outbreak-and-global-pandemic with badly affecting advanced-medical-science-technology-communication-agriculture-agronomy-plant-breeding-horticulture, health-environment-socio-economy, and different-issues. India's emphasis on okra, the ‘Nature's-Gift to Human-Disease-Free-Healthy-Life’ and the most ‘Economically-Important-Number-One-Consumption Vegetable-Crops’ is destroyed by various-diseases causing pathogens like the root-knot (RK)-diseases caused by the nematodes, Meloidogyne incognita (Kofoid & White) Chitwood, and easily checked by many chemical-pesticides. But it causes different carcinogenic effects on the environment and our life. So it is an urgent need to develop potential biomedicines. The pretreatments with ultra-high-diluted-biomedicines (UHDBMs) Gall 200C and Nematode 200C, prepared from okra-root-galls (ORG) and nematode-females (NF) respectively, applied by foliar spray@ 20 ml/plant, are highly effective against the root-knot-disease of okra, Abelmoschus esculentus (L.) Moench Cv. Ankur-40, with the increasing growth of plants and fruits-production. The UHDBMs-Gall 200C is more effective than the Nematode 200C. Both the pretreatments-UHDBMs are responsible for induce-systemic-acquired-defense-response of the pretreated-plants through the expression of pathogenesis-related (PR)-proteins-genes (22-14 numbers), which are more or less similar-molecular-range (295kD-11kD) of many coronavirus, which will be responsible for preventing-RK and COVID-19 like virus-diseases by inducing-defense-resistance or increasing innate-immunity respectively, and advanced in medical-science, technology, communication, agriculture, agronomy, plant breeding, horticulture, health, environment, socio-economy, and different application-issues with pollution-free globe, developing new-preventive typical-biomedical vaccines or treatments methods or drug development and research against the ‘21st-Century Global Pandemic COVID-19 like Any Viral Diseases’ which lead to optimal contributions to the field of policymaking drug and vaccine development emphasizing new or important aspects of the study, and synthetic production of UHDBMs will be more practical implications, and social implications in the future research. And the farmers and the world would be benefitted most; by collecting and uprooting gall-roots after harvesting for cost-effective bio-controlling plant-diseases, and profit from shelling-and-buying of whole plants, fruits, and gall-roots also, and helps for the benefit of global health by developing the most cost-effective, personalized, non-toxic, easily-preparable, easily-maintainable, easily-available and suppliable, vaccines or treatments methods from their own product.
Highlights
It is reported that the genetic variants have a strong statistical association with a person’s chances of developing severe COVID-19, and genome studies have discovered some genetic risk factors for disease [22]. It has revealed the importance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission from pre-symptomatic, asymptomatic, and mildly symptomatic (PAMS) cases, the virological basis of their infectiousness remains largely unquantified, and the reasons for the rapid spread of variant lineages of concern, such as B.1.1.7, have yet to be fully determined, and individual and network heterogeneity for a pandemic; in some countries has been the failure to understand, and take account of, the multilayered systemic interdependencies that spread the effects of the pandemic across social, technological, economic and health-care dimensions, and for viral transmission and evolution dynamics of SARS-CoV-2 in shipboard quarantine [23,24,25,26]
The number of fruits and protein content in green fruit was significantly reduced in inoculated untreated plants as compared to the uninoculated ones, and both the pretreatments with biomedicines; Gall 200C, and Nematode 200C showed better plant growth and lesser intensity of the root-knot disease, and Gall 200C showed the best results in all respect (Table 1)
Both the pretreatment groups of okra plants (OP) treated with ultra-high-diluted biomedicines; Gall 200C, and Nematode 200C, decreased RK-diseases in terms of nematode infection, number of root galls, and nematode population of root in comparison to inoculated untreated groups, and the population of nematode in the soil was the maximum with both the group treated with Gall 200C, and Nematode 200C -biomedicines, and minimum with the inoculated untreated group, due to potential ultra-high-diluted effects of biomedicines, and it is showed that the biomedicines; Gall 200C, and Nematode 200C, might induce synthesis of some antagonistic substance in the treated-OP, which is proved from the inoculated untreated okra root galls (ORG) contained the highest protein-content due to presence of a large number of nematodes [3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,71]
Summary
It is reported that the genetic variants have a strong statistical association with a person’s chances of developing severe COVID-19, and genome studies have discovered some genetic risk factors for disease [22] It has revealed the importance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission from pre-symptomatic, asymptomatic, and mildly symptomatic (PAMS) cases, the virological basis of their infectiousness remains largely unquantified, and the reasons for the rapid spread of variant lineages of concern, such as B.1.1.7, have yet to be fully determined, and individual and network heterogeneity for a pandemic; in some countries has been the failure to understand, and take account of, the multilayered systemic interdependencies that spread the effects of the pandemic across social, technological, economic and health-care dimensions, and for viral transmission and evolution dynamics of SARS-CoV-2 in shipboard quarantine [23,24,25,26]. A growing share of infections among unvaccinated youths in many countries due to an ever-increasing proportion of new infections is in younger age groups [27]
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