Genes involved in nonhost disease resistance as a key to engineer durable resistance in crops

Abstract

Most potential pathogens fail to establish virulence for a plethora of plants found in nature. This intrinsic property to resist pathogen virulence displayed by organisms without triggering canonical resistance (R) genes has been termed nonhost resistance (NHR). While host resistance involves recognition of pathogen elicitors such as avirulence factors by bona fide R proteins, mechanism of NHR seems less obvious, often involving more than one gene. We can generally describe NHR in two steps: 1) pre-invasive resistance, either passive or active, which can restrict the pathogen from entering the host, and 2) post-invasive resistance, an active defense response that often results in hypersensitive response like programmed cell death and reactive oxygen species accumulation. While PAMP-triggered-immunity (PTI) is generally effective against nonhost pathogens, effector-triggered-immunity (ETI) can be effective against both host and nonhost pathogens. Prolonged interactions between adapted pathogens and their resistant host plants results in co-evolution, which can lead to new pathogen strains that can be virulent and cause disease on supposedly resistant host. In this context, engineering durable resistance by manipulating genes involved in NHR is an attractive approach for sustainable agriculture. Several genes involved in NHR have been characterized for their role in plant defense. In this review, we report genes involved in NHR identified to date and highlight a few examples where genes involved in NHR have been used to confer resistance in crop plants against economically important diseases.