Abstract
FoxA, an evolutionarily conserved gene involved in the development of the digestive system in many animals, has an important role in regeneration in flatworms.
Highlights
Regeneration in planarians depends on the presence of stem cells called neoblasts
Are there different types of stem cell that form different tissues? Do signals produced by nearby cells cause specific tissues to form? Or is a combination of both stem cell bias and local signalling used? in eLife, Alejandro Sánchez Alvarado and colleagues at the Stowers Institute for Medical Research— including Carolyn Adler as first author—have provided new insights into this question by developing a method to remove the pharynx, the feeding organ of the worm, to study organ-specific regeneration (Adler et al, 2014)
Blocking stem cell function by irradiation, or by RNA interference knockdown of stem cell-specific genes, prevented regeneration, which suggests that neoblasts have a crucial role in the regeneration of the pharynx
Summary
Regeneration in planarians depends on the presence of stem cells called neoblasts. It is still not entirely clear how the stem cells regenerate specific organs. Are there different types of stem cell that form different tissues?
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