Abstract
Genes for endosomal NHE6 and NHE9 are misregulated in autism brains
Highlights
Genes for endosomal NHE6 and NHE9 are misregulated in autism brains
In addition to observing autism symptoms in the monogenic condition, if the gene responsible is significantly misregulated in the brains of people with idiopathic autism, these data provide substantial independent support for the importance of the gene in autism pathophysiology
We report a strong correlation of endosomal NHE6 and NHE9 gene expression with the synapse genes across all data sets
Summary
Genes for endosomal NHE6 and NHE9 are misregulated in autism brains Voineagu et al.[6] reported that synapse-associated genes were downregulated in autism cortex,[6] and we confirmed this result by performing differential gene expression analysis[7] between autism and control cortex (for detailed Methods, please see Supplementary Information). This confirmed that synapse-related genes, such as GABRA1 and CHRM1, were downregulated in autism cortex in the Voineagu et al.[6] data set (Supplementary Tables 1 and 2 for description of the downregulated synapse genes).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
