Abstract
Genes and cognitive aging
Highlights
In the same issue of this journal, Nagel et al (2008) used a cross-sectional approach and looked at two different cognitive tasks and found strong evidence of both an age × catechol-O-methyl transferase (COMT) genotype and a three-way interaction with the brain-derived neurotrophic factor (BDNF) allele in which the Met allele in COMT Val carriers was detrimental. These results follow on previous studies that have been inconsistent in many ways
The most substantive differences between them today are that Vision Egg offers relatively simple perspective corrected stimuli utilizing the 3D www.frontiersin.org
Summary
A commentary on Genetic contributions to age-related decline in executive function: a 10-year longitudinal study of COMT and BDNF polymorphisms by Kirk I. In the same issue of this journal, Nagel et al (2008) used a cross-sectional approach and looked at two different cognitive tasks (the Wisconsin Card Sorting Test and a spatial working memory task) and found strong evidence of both an age × COMT genotype (such that older subjects with the Val allele were poorer performers than Met homozygotes) and a three-way interaction with the BDNF allele in which the Met allele in COMT Val carriers was detrimental These results follow on previous studies that have been inconsistent in many ways.
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