Abstract
BackgroundTo determine generic utilities for Spanish chronic obstructive pulmonary disease (COPD) patients stratified by different classifications: GOLD 2007, GOLD 2013, GesEPOC 2012 and BODEx index.MethodsMulticentre, observational, cross-sectional study. Patients were aged ≥40 years, with spirometrically confirmed COPD. Utility values were derived from EQ-5D-3 L. Means, standard deviations (SD), medians and interquartile ranges (IQR) were computed based on the different classifications. Differences in median utilities between groups were assessed by non-parametric tests.Results346 patients were included, of which 85.5% were male with a mean age of 67.9 (SD = 9.7) years and a mean duration of COPD of 7.6 (SD = 5.8) years; 80.3% were ex-smokers and the mean smoking history was 54.2 (SD = 33.2) pack-years. Median utilities (IQR) by GOLD 2007 were 0.87 (0.22) for moderate; 0.80 (0.26) for severe and 0.67 (0.42) for very-severe patients (p < 0.001 for all comparisons). Median utilities by GOLD 2013 were group A: 1.0 (0.09); group B: 0.87 (0.13); group C: 1.0 (0.16); group D: 0.74 (0.29); comparisons were statistically significant (p < 0.001) except A vs C. Median utilities by GesEPOC phenotypes were 0.84 (0.33) for non exacerbator; 0.80 (0.26) for COPD-asthma overlap; 0.71 (0.62) for exacerbator with emphysema; 0.72 (0.57) for exacerbator with chronic bronchitis (p < 0.001). Comparisons between patients with or without exacerbations and between patients with COPD-asthma overlap and exacerbator with chronic bronchitis were statistically-significant (p < 0.001). Median utilities by BODEx index were: group 0–2: 0.89 (0.20); group 3–4: 0.80 (0.27); group 5–6: 0.67 (0.29); group 7–9: 0.41 (0.31). All comparisons were significant (p < 0.001) except between groups 3–4 and 5–6.ConclusionIrrespective of the classification used utilities were associated to disease severity. Some clinical phenotypes were associated with worse utilities, probably related to a higher frequency of exacerbations. GOLD 2007 guidelines and BODEx index better discriminated patients with a worse health status than GOLD 2013 guidelines, while GOLD 2013 guidelines were better able to identify a smaller group of patients with the best health.
Highlights
To determine generic utilities for Spanish chronic obstructive pulmonary disease (COPD) patients stratified by different classifications: Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2007, GOLD 2013, GesEPOC 2012 and BODEx index
In 2012, in recognition of the heterogeneity of COPD, the Spanish Society of Pulmonology and Thoracic Surgery, together with the scientific societies involved in the health care of COPD patients, produced new clinical practice guidelines (GesEPOC) [6] based on the clinical phenotypes of COPD and proposed a COPD severity classification based on the BODEx index
GesEPOC phenotypes differentiated between COPD patients regardless of their GOLD 2007 classification
Summary
To determine generic utilities for Spanish chronic obstructive pulmonary disease (COPD) patients stratified by different classifications: GOLD 2007, GOLD 2013, GesEPOC 2012 and BODEx index. Airflow obstruction is only one aspect of COPD, as there are other aspects like reduced muscle strength, dyspnoea or functional impairment in daily activities that are key components of the health status of COPD patients. For this reason, GOLD 2013 update [5] proposed a combined assessment of COPD severity including lung function, the history of exacerbations and the presence of symptoms. In 2012, in recognition of the heterogeneity of COPD, the Spanish Society of Pulmonology and Thoracic Surgery, together with the scientific societies involved in the health care of COPD patients, produced new clinical practice guidelines (GesEPOC) [6] based on the clinical phenotypes of COPD and proposed a COPD severity classification based on the BODEx index
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
