Abstract
The use of liquid chromatography/mass spectrometry (LC/MS) methodologies has revolutionized the way compounds are analyzed in the pharmaceutical industry due to its high selectivity and high sensitivity. At Cephalon, we have developed a single generic method that we use for our entire high throughput absorption, distribution, metabolism and excretion (ADME) screening. The generic method eliminates the need to develop a new method for each new compound being screened and tremendously reduces sample preparation time by using turbulent flow chromatography for on-line extraction of biological matrices. The combination of several different in vitro and in vivo screens that are all analyzed by a single LC/MS/MS method allows us to generate data for lead candidate selection rapidly with minimum effort.
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