Abstract
Abstract As discussed in Chapter 1.1, health status measures can be generic or disease-targeted. Generic health status measures are intended to be applicable across all diseases or conditions, across different medical interventions, and across a wide range of populations (Patrick and Deyo 1989). In clinical trials, a targeted measure may provide more detailed outcome information regarding changes in the particular patient population. In addition, targeted measures may be perceived as being more relevant to patients, clinicians, and researchers (Guyatt et al. 1993). However, use of both targeted and generic measures may be optimal in most clinical trials. By using only a targeted measure, the general or overall impact on functioning and well-being may be missed.
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