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Abstract
We have examined the generation of second messengers after stimulation of feline, bovine, human iris-sphincter and ciliary muscles by selected prostaglandins (PGs). The tissues, labeled or unlabeled with 3H-myo-inositol, were stimulated by a range of concentrations of 16, 16-dimethyl PGE 2, 11-deoxy PGE 1, 17-phenyl trinor PGE 2 and PGF 2α. In both tissues of all three species, 16, 16-dimethyl PGE 2 and 11-deoxy PGE 1 stimulated the formation of cyclic AMP. Butaprost, an EP 2 receptor agonist, which was tested only in feline ciliary muscle, generated cyclic AMP. In the feline iris-sphincter and in bovine and feline ciliary muscles, 17-phenyl trinor PGE 2, an EP 1 receptor agonist, significantly increased inositol phosphate turnover. The FP receptor agonist, PGF 2α stimulated inositol phosphate turnover in the bovine, feline, and human iris-sphincter muscles and in human ciliary muscles. Feline and bovine ciliary muscles did not respond to PGF 2α. These results suggest that EP 1 receptors are present in feline iris-sphincter muscle and in bovine and feline ciliary muscles. The EP 2 receptors exist in both tissue. These results also suggest the presence FP receptors in bovine, feline, and human iris-sphincter and in human ciliary muscles. Bovine and feline ciliary muscles do not appear to express FP receptors.
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