Abstract
Metallothioneins belong to a superfamily of intracellular metal-binding proteins, have bearing on almost all biochemical processes,include free radical scavenging, apoptosis, regulation of intracellular redox balance, and anti-inflammatory processes. By using a CRISPR/Cas 9 system, we generated Mt3-/- mES line. This cell line has contributed to further investigation of the functions of Mtt3 during early development, as well as a cell model for screening for metal-related detoxificationan and antioxidant response phenotype during stem cell differentiation.
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