Abstract
As a privileged motif, the indene core can be found in many natural products and pharmaceuticals. Our continued interest in the construction of natural product like compounds prompted us to develop efficient and mild protocols for the generation of indene derivatives. This account describes two typical procedures that involve tandem reactions: a base-mediated cyclization of 1-alkenyl-2-arylalkynes and a palladium-catalyzed annulation of 1-alkynyl-2-halobenzenes. Diversity and complexity can be easily incorporated during these reaction processes. 1 Introduction 2 Synthesis of Indene Derivatives by Base-Promoted Cyclization of (2-Alkenylphenyl)alkynes 3 Formation of Indenes by Palladium-Catalyzed Reactions of gem-Dibromoolefins 4 Palladium-Catalyzed Reactions of 1-Alkynyl-2-bromobenzenes 5 Outlook and Conclusion
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