Abstract
Evidence highlights the concept of multiple trajectories leading to COPD. Early-life events (i.e., in utero lung development) may influence the maximally attained lung function and increase the risk to develop COPD. Human pluripotent stem cells (hiPSC) represent a unique opportunity to model lung development. We generated hiPSC lines from four highly characterized COPD patients with early onset and severe phenotype. Peripheral blood mononuclear cells (PBMCs) were reprogrammed using integration-free Sendai Virus. The cell lines had normal karyotype, expressed pluripotency hallmarks, and differentiated into the three primary germ layers.These lines offer a tool to study early-life origins of COPD.
Highlights
To cite this version: Engi Ahmed, Mathieu Fieldes, Joffrey Mianné, Chloé Bourguignon, Amel Nasri, et al
The documents may come from teaching and research institutions in France or abroad, or from public or private research centers
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Summary
To cite this version: Engi Ahmed, Mathieu Fieldes, Joffrey Mianné, Chloé Bourguignon, Amel Nasri, et al..
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