Generation of Aryl Grignard Reagents from Arene Chromium Tricarbonyl Complexes by Mg(TMP)2·2LiCl and Their Application to Murahashi Coupling

Abstract

A mild and straightforward synthesis of biaryls is described that is performed through direct arylation of the C–H bond of (arene)Cr(CO)3 upon deprotonation with Mg(2,2,6,6-tetramethylpiperazide)2·2LiCl and subsequent palladium-catalyzed cross-coupling reaction.