Abstract
It has been proposed that impaired degradation is the cause of amyloid A (AA) formation in reactive amyloidosis (Ham et al., Scand J Immunol 1997; 45: 354-60). The current SDS-PAGE of the culture medium showed that the macrophage cell line from the amyloid-susceptible mouse strain (ANA1) degraded amyloid precursor protein serum amyloid A into the AA-like amyloidogenic product of approximately 8.6 kDa but went no further, whereas cells from the resistant strain (A/J10) cleared the AA-like derivates proceeding to approximately 7.7 kDa products within the incubation period. Degradation occurred in the chemically defined medium at a slower rate than in the medium with serum. This may imply that a lack of the serum components as well as impaired degradation could contribute to the development of amyloidosis.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
