Abstract
Neutrophil-activating peptide 2(NAP-2) is a peptide which was first isolated from the culture supernatants of stimulated human blood mononuclear cells [1]. Sequence analysis and carboxy-terminus determination showed that it consists of 70 amino acids and results from the truncation of platelet basic protein (PBP) [2] and connective tissue activating peptide III (CTAP-III) [3], both of which are released from alpha granules following platelet stimulation. NAP-2 has considerable sequence homology with neutrophil-activating peptide 1/interleukin-8 (NAP-1/IL-8) [1], melanoma growth-stimulatory activity (gro/MGSA) [4, 5], platelet factor 4 (PF-4) [6], and γ-IP10, a γ-interferon inducible cytokine [7] (Fig. 1).
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