Abstract
Tick-borne encephalitis (TBE), caused by TBE virus (TBEV), is one of the most serious human viral diseases endemic in Europe and East Asia. No effective treatment for TBEV infection exists and the primary preventive measure is vaccination. Although several inactivated vaccines have been licensed, the development of novel and more effective vaccines remains a high priority especially in disease-endemic countries. Here we describe a universal vaccine design approach to construct a live chimeric recombinant TBEV attenuated strain ChinTBEV based on the infectious full-length cDNA clone of Japanese encephalitis virus using standard reverse genetic technology. The in vitro and in vivo characterization of the ChinTBEV is also presented here.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
