Abstract
An IgG1 mouse monoclonal antibody (MAb) YPC3 against human pancreatic carcinoma was generated by a hybridoma technique. When human tissue sections were examined with immunohistochemical staining, YPC3 MAb reacted with 28 of 32 (87.5%) cases of pancreatic carcinoma tissue; it failed to react with all 11 cases of normal pancreas examined. When 99mTC-radiolabeled YPC3 MAb was administrated intravenously to the nude mice bearing xenograft of pancreatic carcinoma, clear scintigraphic visualization of tumor xenograft was found with SPECT 24 h after injection. Administration of either YPC3 MAb or LAK cells combined with YPC3 MAb could inhibit the growth of the xenografts in nude mice. These results suggest that YPC3 MAb might be an ideal carrier for radioimmunolocalization and immunotherapy of human pancreatic carcinoma.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
