Abstract
Creating protein capture reagents on a proteome-wide scale is a grand challenge in molecular medicine.[1] High quality reagents are critical for elucidating protein function, and developing diagnostic and therapeutic agents. Although antibodies remain the gold standard, their cumbersome production in animals is expensive, time consuming, and can fail for many targets.[2] Alternative technologies like single-chain antibodies and aptamers overcome some of these limitations, but still require many iterative rounds of selection and amplification to produce high quality binders.[3] Problems such as these have created a pressing need for next generation technologies that lend themselves as tools to explore the human proteome, but are more efficient and cost-effective to produce than existing reagents. Ideal protein capture reagents would be constructed with minimal effort from easy-to-assemble building blocks that are readily available and inexpensive.[4] The most promising reagents would function in assays that already exist for antibodies.
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