Generalized Lymphadenapathy - An Unusual Presentation of Sarcoidosis

Aparna Das,Maruf Chowdhury ,Abdelmoniem Mostafa ,Mahmud Hasan ,Ma Kahhar

doi:10.3329/jom.v15i1.19874

Aparna Das, Maruf Chowdhury + Show 3 more

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https://doi.org/10.3329/jom.v15i1.19874

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Abstract

Sarcoidosis is a systemic granulomatous disease of unknown origin. It is manifested pathologically by the presence of noncaseating granulomas containing multinucleated giant cells,although other granulomatous diseases may produce identical findings. The vast majority of patients have thoracic sarcoidosis with bilateral hilar lymphadenopathy and/or bronchonodular pulmonary infiltrates on chest radiographs. About 40% of patients have extrathoracic disease involving the eye, skin, lymph nodes, liver, spleen, heart, and musculoskeletal or nervous system. Here we report a case of sarcoidosis who presented only with generalized lymphadenopathy.DOI: http://dx.doi.org/10.3329/jom.v15i1.19874 J Medicine 2014; 15: 58-60

Highlights

IntroductionSarcoidosis is a multisystem granulomatous disorder characterized pathologically by the presence of noncaseating granulomas in involved organs, occurring in patients between 10 and 40 years of age in 70 to 90 percent of cases
Sarcoidosis is a multisystem granulomatous disorder characterized pathologically by the presence of noncaseating granulomas in involved organs, occurring in patients between 10 and 40 years of age in 70 to 90 percent of cases. It typically presents with bilateral hilar lymphadenopathy, pulmonary reticular opacities, and skin, joint or eye lesions
We report a case of sarcoidosis for its unusual presentation without typical clinical features

Summary

Introduction

Sarcoidosis is a multisystem granulomatous disorder characterized pathologically by the presence of noncaseating granulomas in involved organs, occurring in patients between 10 and 40 years of age in 70 to 90 percent of cases. It typically presents with bilateral hilar lymphadenopathy, pulmonary reticular opacities, and skin, joint or eye lesions. Up to 30 percent of patients present with extrapulmonary disease 1.The incidence of the disease varies among geographical regions It occurs more commonly, three to four times in blacks in the United States of America.[3] Sarcoidosis, though rare in our community, should still be considered in the differential diagnosis of patients with the typical presentation after excluding tuberculosis. We report a case of sarcoidosis for its unusual presentation without typical clinical features

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