Abstract
DNCB- and DNCBSO<sub>3</sub>-sensitized guinea pigs were injected i.v. with DNCBSO<sub>3</sub>. The following phenomena were recorded: (1) the test reaction to DNCB was inhibited; (2) generalized dermatitis arose, and (3) eosinophilic infiltration occurred spotwise in the epidermis. DNCB- and DNCBSO<sub>3</sub>-sensitized guinea pigs were united with normal guinea pigs in arteriovenous anastomosis and the sensitized guinea pig was given DNCBSO<sub>3</sub> i.v. The aforementioned phenomena occurred in the sensitized guinea pig. The normal guinea pig reacted with generalized dermatitis, but only in a few experiments with epidermal eosinophilia. The same results were obtained when the normal guinea pig was injected with DNCBSO<sub>3</sub>.
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