Generalized cytomegalic inclusion disease presenting an infectious mononucleosis syndrome (so-called cytomegalovirus mononucleosis) in a previously healthy adult--an autopsy study.

Abstract

Autopsy study of generalized cytomegalic inclusion disease with distinct clinical manifestation of Paul‐Bunnel negative infectious mononucleosis in a previously healthy, 73 years old male revealed almost ubiquitous infiltration of lymphocyte and atypical lymphocyte in close association with existence of typical cytomegalic inclusion laden cells. Besides intense cytomegalovirus pneumonitis, hepatitis, orchitis and lesions in many other organs, similar cellular proliferation and infiltration were especially severe in the reticuloendothelial and hematopoietic systems including grossly only slightly enlarged lymphnodes, bone marrow and moderately swollen spleen. Lymphoproliferative response in these organs was outstanding, whereas reaction of reticulum cell and histiocyte was less marked. Such a peculiar distribution and nature of the lesion was thought to consist some morphological characteristics in this type of generalized cytomegalic inclusion disease.