Generalized Bullous Fixed Drug Eruption to Iodinated Contrast Media in Skin of Color

Abstract

A 69-year-old Malay woman presented with a widespread painful blistering rash, which had first begun over her neck and trunk, a few hours after a computed tomography scan performed with 90 mL of iohexol contrast for surveillance of sigmoid adenocarcinoma. Examination was notable for multiple circular hyperpigmented patches with inlying blisters and well-demarcated erosions involving her upper lip, neck, abdomen, and lower extremities (Figures 1 and 2). The total area of detachable epidermis was approximately 25%.