General unbiased estimating equations for variance components in linear mixed models

Abstract

This paper introduces a general framework for estimating variance components in the linear mixed models via general unbiased estimating equations, which include some well-used estimators such as the restricted maximum likelihood estimator. We derive the asymptotic covariance matrices and second-order biases under general estimating equations without assuming the normality of the underlying distributions and identify a class of second-order unbiased estimators of variance components. It is also shown that the asymptotic covariance matrices and second-order biases do not depend on whether the regression coefficients are estimated by the generalized or ordinary least squares methods. We carry out numerical studies to check the performance of the proposed methods based on typical linear mixed models.